WORK PACKAGE 4

Data search, extraction and synthesis of evidence

Main objectives:

  • To collect all necessary data from randomised controlled trials (RCTs) for the comparative analysis of self-management interventions (SMIs)
  • To synthesise all available evidence on SMIs from published RCTs

Approach:

To identify relevant studies (RCTs), we build on our previous experience from other European projects (Pro-STEP, EMPATHiE) in which hundreds of systematic reviews on self-management interventions for diabetes, obesity, COPD, and heart failure were identified. We update the searches to include new studies published. After reviewing all included RCTs, we extract key information of relevant variables selected (according to criteria established in WP2). These variables include condition type (and comorbidities), patient characteristics and subgroups (comorbidity, gender and socio-economic dimensions), intervention types and characteristics, selected outcomes and results, and information of the study quality assessment. Finally, we synthesise the findings on SMIs and SMI outcomes from all RCTs to use in further analysis. Using the GRADE system, which considers risk of bias, inconsistency, directness, imprecision, and publication bias, we evaluate the quality of evidence for each comparison.

Leading partner: Netherlands Institute for Health Services Research (Nivel), The Netherlands

Other partners involved:

  • Fundación Avedis Donabedian (FAD), Spain
  • Institute for Medical Technology Assessment (iMTA), The Netherlands
  • Fundació Privada Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau (IR-HSCSP), Spain
  • University of Ioannina (UOI), Greece